A technological renaissance is here due to advances in computer technology and an awareness of incorporating biologics and genomics into medicine and dentistry. Advances in communication, construction, teaching and medicine have all benefited from this technology. CEREC, or ceramic reconstruction, has finally reached a level of accuracy that surpasses the accuracy of indirect restorations made by hand, and digital radiography is now the standard in imaging. The major areas of dentistry that will see an explosion of technology will be presented. The fastest growing area of dentistry is imaging using a variety of digital instruments to accurately obtain two and three-dimensional images in real time. This technology will be used in all aspects of dentistry, but in particular, diagnosis and treatment planning. New aspects of imaging will involve using three-dimensional imaging in real time to discover cracks in teeth, and mapping of caries throughout a tooth. A movement away from metal and ceramic will occur with the use of bioactive and smart materials, and materials that will regenerate tooth structures, perhaps with stem cells. Three-dimensional printing will become the standard for the fabrication of everything in the office. Devices using technology from the airline industry, using heads-up-display and recognition software, will make dentistry safer. Most importantly, the profession will come to embrace that all patients are unique in their genetic makeup, and personalized medicine will become standard treatment for patients in the future.